Interferon- Suppresses Cyclooxygenase-2 Promoter Activity by Inhibiting C-Jun and C/EBP Binding
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منابع مشابه
Salicylate Suppresses Macrophage Nitric-oxide Synthase-2 and Cyclo-oxygenase-2 Expression by Inhibiting CCAAT/Enhancer- binding Protein- Binding via a Common Signaling Pathway*
We determined whether salicylate at pharmacological concentrations inhibits nitric-oxide synthase-2 (NOS-2) and cyclo-oxygenase-2 (COX-2) expressions in RAW 264.7 stimulated with lipopolysaccharide (LPS) and interferon(IFN). Cells were treated with sodium salicylate (10 -10 4 M) or vehicle for 30 min followed by LPS IFNfor up to 24 h. Salicylate suppressed NOS-2 and COX-2 protein levels and pro...
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Inhibition of ubiquitin-proteasome pathway has been shown to be a promising strategy for the treatment of inflammation and cancer. Here, we show that proteasome inhibitors MG132, PSI-1, and lactacystin induce COX-2 expression via enhancing gene transcription rather than preventing protein degradation in the human alveolar NCI-H292 and A549, and gastric AGS epithelial cells. NF-IL6 and CRE, but ...
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BACKGROUND Cyclooxygenase-2 (COX-2) plays a key role in human inflammatory disorders such as vascular inflammation. COX-2 promoter activity is induced by proinflammatory mediators, but the role of cyclic adenosine monophosphate response element (CRE) in promoter stimulation remains unclear. METHODS AND RESULTS Transient transfection of a 0.9-kb COX-2 promoter fragment bearing CRE mutation abr...
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NF-IL6beta regulates gene expression and plays function roles in many tissues. The EGF-regulated cyclooxygenase-2 (cox-2) expression is mediated through p38(MAPK) signaling pathway and positively correlates with NF-IL6beta expression in A431 cells. NF-IL6beta coordinated with c-Jun on cox-2 transcriptional activation by reporter and small interfering RNA assays. NF-IL6beta could directly bind t...
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تاریخ انتشار 2007